多焦点视觉诱发电位的眼间比较：一种检测视神经局部损伤的可能技术。
An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve.
作者信息
Hood D C, Zhang X, Greenstein V C, Kangovi S, Odel J G, Liebmann J M, Ritch R
机构信息
Department of Psychology, Columbia University, New York, New York 10027, USA.
出版信息
Invest Ophthalmol Vis Sci. 2000 May;41(6):1580-7.
PURPOSE
To develop a quantitative measure of local damage to the ganglion cells/optic nerve based on an interocular comparison of multifocal visual evoked potentials (mVEP).
METHODS
Multifocal VEPs were recorded from both eyes of six normal subjects and four patients; each eye was stimulated separately. Two of the patients had glaucoma, one had ischemic optic neuropathy, and one had unilateral optic neuritis. All four patients had considerably more damage in one eye than in the other, as indicated by their Humphrey visual fields. The multi-input procedure of Sutter was used to obtain 60 VEP responses to a scaled checkerboard pattern. The amplitude in each response was obtained using a root mean square measure of response magnitude. For each of the 60 pairs of responses, a ratio between the amplitude of the responses from the two eyes was obtained as a measure of the relative health of one eye compared with the other. The mean and SD of this ratio measure for the control group were used to specify confidence intervals for each of the 60 locations. All patients had Humphrey 24-2 visual fields performed. To allow a comparison of the mVEPs to the visual fields, a procedure was developed for displaying the results of both tests on a common set of coordinates.
RESULTS
Except for a small interocular difference in timing attributable to nasotemporal retinal differences, the pairs of mVEP responses from the two eyes of the control subjects were essentially identical. Many of the pairs of responses from the patients were significantly different. In general, there was reasonably good agreement with the Humphrey 24-2 visual field data. Although some regions with visual field defects were not detected in the mVEP due to small responses from the better eye, other abnormalities were detected that were hard to discern in the visual fields.
CONCLUSIONS
Local monocular damage to the ganglion cell/optic nerve can be quantitatively measured by an interocular comparison of the mVEP.
目的
基于多焦视觉诱发电位（mVEP）的眼间比较，开发一种定量测量神经节细胞/视神经局部损伤的方法。
方法
记录了6名正常受试者和4名患者双眼的多焦VEP；每只眼睛分别进行刺激。4名患者中有2名患有青光眼，1名患有缺血性视神经病变，1名患有单侧视神经炎。根据他们的 Humphrey 视野检查结果，所有4名患者的一只眼睛损伤程度明显比另一只眼睛严重。使用Sutter的多输入程序获得对缩放棋盘图案的60个VEP反应。每个反应的幅度通过反应幅度的均方根测量获得。对于60对反应中的每一对，获得两眼反应幅度之间的比率，作为一只眼睛与另一只眼睛相对健康状况的指标。对照组该比率测量的平均值和标准差用于确定60个位置中每个位置的置信区间。所有患者均进行了Humphrey 24-2视野检查。为了将mVEPs与视野进行比较，开发了一种程序，以便在一组共同的坐标上显示两项测试的结果。
结果
除了由于鼻颞侧视网膜差异导致的眼间时间上的微小差异外，对照组双眼的mVEP反应对基本相同。患者的许多反应对存在显著差异。总体而言，与Humphrey 24-2视野数据有较好的一致性。尽管由于较好眼睛的反应较小，mVEP中未检测到一些视野缺损区域，但检测到了其他在视野中难以辨别的异常情况。
结论
通过mVEP的眼间比较可以定量测量神经节细胞/视神经的局部单眼损伤。
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