van Beek N, Griez E
Department of Psychiatry, University Maastricht, The Netherlands.
Biol Psychiatry. 2000 May 1;47(9):830-5. doi: 10.1016/s0006-3223(99)00265-6.
The effects of a 35% CO2 challenge were examined in healthy first-degree relatives of panic disorder patients and in healthy control subjects matched for age and gender.
One single inhalation of a 35% CO2/65% O2 challenge was administered to 50 first-degree relatives of panic disorder patients and 50 control subjects.
The first-degree relatives were more reactive to the 35% CO2 challenge than the control subjects.
These findings indicate that being a member of a family with a panic disorder patient is, in itself an important factor in CO2 hypersensitivity among subjects who have never experienced a panic attack. Both panic disorder patients and their first-degree relatives have a tendency to be more reactive to the CO2 challenge.
在惊恐障碍患者的健康一级亲属以及年龄和性别匹配的健康对照者中，研究了35%二氧化碳激发试验的效果。
对50名惊恐障碍患者的一级亲属和50名对照者进行单次吸入35%二氧化碳/65%氧气激发试验。
一级亲属对35%二氧化碳激发试验的反应比对照者更强烈。
这些发现表明，对于从未经历过惊恐发作的个体而言，作为惊恐障碍患者家庭的一员本身就是二氧化碳超敏反应的一个重要因素。惊恐障碍患者及其一级亲属对二氧化碳激发试验往往有更强的反应。
