Perna G, Cocchi S, Bertani A, Arancio C, Bellodi L
Department of Neuropsychiatric Sciences, Instituto Scientifico H. San Raffaele, University of Milan, Italy.
Am J Psychiatry. 1995 Apr;152(4):623-5. doi: 10.1176/ajp.152.4.623.
The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder.
One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first-degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder.
The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands.
These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.
作者检验了如下假设，即健康受试者对二氧化碳的高反应性代表了惊恐障碍潜在的家族易感性。
对84例惊恐障碍患者、23名惊恐障碍先证者的健康一级亲属以及44名无惊恐障碍家族史的健康受试者，分别进行一次肺活量吸入35%二氧化碳和65%氧气的测试。
惊恐障碍先证者的一级亲属的反应明显比健康受试者强烈，但明显弱于先证者。
这些发现表明惊恐障碍家族史与健康受试者对35%二氧化碳的高反应性之间存在关联。
