Perna G, Gabriele A, Caldirola D, Bellodi L
Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, Italy.
Psychiatry Res. 1995 Aug 28;57(3):267-73. doi: 10.1016/0165-1781(95)02723-a.
Thirteen healthy subjects with infrequent panic attacks and without agoraphobia who did not meet DSM-III-R criteria for panic disorder, 43 patients with panic disorder, and 43 healthy control subjects who never experienced panic attacks underwent one vital capacity inhalation of 35% CO2. Healthy subjects with infrequent panic attacks reacted similarly to patients with panic disorder and more strongly than healthy subjects who never experienced panic attacks. The results suggest that (a) subjects with sporadic unexpected panic attacks and patients with panic disorder belong to the same spectrum of vulnerability and (b) CO2 hypersensitivity might be a trait marker of panic attacks rather than of a clinical diagnosis of panic disorder.
13名偶尔出现惊恐发作且无广场恐惧症、不符合DSM-III-R惊恐障碍标准的健康受试者，43名惊恐障碍患者，以及43名从未经历过惊恐发作的健康对照受试者接受了一次吸入35%二氧化碳的肺活量测试。偶尔出现惊恐发作的健康受试者与惊恐障碍患者的反应相似，且比从未经历过惊恐发作的健康受试者反应更强烈。结果表明：（a）偶发性意外惊恐发作的受试者和惊恐障碍患者属于同一易损谱；（b）二氧化碳高敏反应可能是惊恐发作的一个特质标记，而非惊恐障碍临床诊断的特质标记。
