Yang Z P, Kuo C C, Grayston J T
Department of Pathobiology, University of Washington, Seattle 98195.
Infect Immun. 1993 May;61(5):2037-40. doi: 10.1128/iai.61.5.2037-2040.1993.
Chlamydia pneumoniae is a common cause of acute respiratory infections in humans. We evaluated mice as experimental animals for C. pneumoniae. Intranasal inoculation of Swiss Webster mice with C. pneumoniae induced a prolonged course of lung infection, as demonstrated by reisolation of organisms from lungs (at 42 days) and persistence of lung pathology (> 60 days). The lung pathology was characterized by patchy interstitial pneumonitis with predominantly polymorphonuclear leukocyte infiltration in the early and mononuclear cell infiltration in the later stages of infection. Inoculated mice developed serum immunoglobulin G antibody responses and partial resistance against rechallenge inoculation. The other mouse strains tested, Icr, BALB/cAnN, C57BL/6N, C3H/HeN, and B6C3F1, were shown to be susceptible to C. pneumoniae. The mouse model should be useful for investigating the immunopathogenesis of C. pneumoniae infections.
肺炎衣原体是人类急性呼吸道感染的常见病因。我们评估了小鼠作为肺炎衣原体实验动物的情况。用肺炎衣原体经鼻接种瑞士韦伯斯特小鼠可引发肺部感染的长期病程，从肺部重新分离出病原体（42天时）以及肺部病理状况持续存在（>60天）即可证明这一点。肺部病理特征为斑片状间质性肺炎，感染早期以多形核白细胞浸润为主，后期以单核细胞浸润为主。接种小鼠产生了血清免疫球蛋白G抗体反应，并对再次接种具有部分抵抗力。所测试的其他小鼠品系，即Icr、BALB/cAnN、C57BL/6N、C3H/HeN和B6C3F1，均显示对肺炎衣原体易感。该小鼠模型应有助于研究肺炎衣原体感染的免疫发病机制。
