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[年龄和辐射暴露对通过荧光原位杂交(FISH)方法检测的人淋巴细胞中易位和双着丝粒频率的影响]

[Effect of age and radiation exposure on the frequency of translocations and dicentrics detected by FISH method in human lymphocytes].

作者信息

Vorobtsova I E, Tucker J D, Timofeeva N M, Bogomazova A N, Semenov A V, Pleshanov P G

机构信息

Gentral Research Institute of Roentgenology and Radiology, Ministry of Health of Russia, St. Petersburg, Russia.

出版信息

Radiats Biol Radioecol. 2000 Mar-Apr;40(2):142-8.

PMID:10819035
Abstract

The frequencies of translocations and dicentrics detected by "chromosome painting" in lymphocytes were estimated in 115 healthy donors and in 273 people exposed to uncontrolled irradiation at low doses 1-4 years ago. Age responses of both types of exchanges at the age range from 3 to 85 years fit to quadratic model. The frequency of translocations grew faster with age than the frequency of dicentrics. The yields of stable exchanges in exposed people was significantly higher than those in control donors of corresponding ages.

摘要

通过“染色体描绘”检测淋巴细胞中易位和双着丝粒的频率,在115名健康供者以及273名在1 - 4年前受到低剂量无控制照射的人群中进行了估算。在3至85岁年龄范围内,这两种类型交换的年龄反应均符合二次模型。易位频率随年龄增长的速度比双着丝粒频率更快。受照射人群中稳定交换的发生率显著高于相应年龄的对照供者。

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引用本文的文献

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J Radiat Res. 2013 Sep;54(5):832-9. doi: 10.1093/jrr/rrt018. Epub 2013 Mar 27.
2
International study of factors affecting human chromosome translocations.影响人类染色体易位因素的国际研究。
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