Sharetskiĭ A N, Surinov B P, Abramova M R
Russian Academy of Medical Sciences, Department of Radiation Immunology, Obninsk, Kaluga region, Russia.
Radiats Biol Radioecol. 2000 Mar-Apr;40(2):168-72.
The exposure of mice to low dose of gamma-rays (10 cGy, 1 cGy/min) increased thymus-dependent humoral immune response and polyclonal activation of B-cells. Injection of hydroquinone eliminated radiation-induced augmentation of polyclonal response of B-lymphocyte. Thymogen decreased significantly the radiation-induced immunostimulation. The study of the dynamics of primary immune response showed that the period of radiation-induced elevation was followed by the phase of profound reduction of antibody formation. Possible negative consequences of action of low doses of ionizing radiation on immune system is discussed.
将小鼠暴露于低剂量γ射线（10 cGy，1 cGy/分钟）可增强胸腺依赖性体液免疫反应以及B细胞的多克隆激活。注射对苯二酚可消除辐射诱导的B淋巴细胞多克隆反应增强。胸腺素可显著降低辐射诱导的免疫刺激。对初次免疫反应动力学的研究表明，在辐射诱导的升高期之后是抗体形成深度降低的阶段。本文讨论了低剂量电离辐射作用于免疫系统可能产生的负面后果。
