Santra M, Talukder G, Sharma A
Department of Pathology, Vivekananda Institute of Medical Sciences, Calcutta, India.
Cytobios. 2000;102(399):55-62.
The clastogenic effects of three different concentrations of zinc chloride on human peripheral blood leucocytes were studied in vitro. The highest concentration (1.5 x 10(-3) M) was lethal after 48 and 72 h of culture and no blast cells were formed. The two lower concentrations (3.0 x 10(-4) M and 3.0 x 10(-5) M) significantly reduced the frequency of cell division, induced chromatid breaks and damaged cells in frequencies significantly higher than in control experiments maintained in sodium chloride and in distilled water.
体外研究了三种不同浓度的氯化锌对人外周血白细胞的致断裂效应。最高浓度（1.5×10⁻³ M）在培养48小时和72小时后具有致死性，未形成母细胞。两个较低浓度（3.0×10⁻⁴ M和3.0×10⁻⁵ M）显著降低细胞分裂频率，诱导染色单体断裂，且受损细胞的频率显著高于在氯化钠和蒸馏水中进行的对照实验。
