Deknudt G
C R Seances Soc Biol Fil. 1982;176(4):563-7.
The eventual clastogenic properties of zinc chloride have been assessed as well in vitro as in vivo studies on mammalian somatic cells. For this purpose, human peripheral lymphocytes were treated in 48 or 72 hours cultures with 0, 20 or 200 micrograms zinc chloride, whereas C57Bl mice have received during one month a normal or poor calcium diet in combination or not with 0.5 g % of zinc. Chromosome analysis of treated human lymphocytes and of bone marrow cells of mice fed a poor dietary calcium supplemented with zinc has shown a significant increase in structural chromosome aberrations.
通过体外和体内对哺乳动物体细胞的研究，评估了氯化锌最终的致染色体断裂特性。为此，在48或72小时的培养中，用0、20或200微克氯化锌处理人外周血淋巴细胞，而C57Bl小鼠在一个月内接受正常或低钙饮食，并分别添加或不添加0.5%的锌。对接受低钙饮食并补充锌的小鼠的骨髓细胞以及经处理的人淋巴细胞进行染色体分析，结果显示染色体结构畸变显著增加。
