Kitagawa H, Kitoh K, Inoue H, Ohba Y, Suzuki F, Sasaki Y
Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan.
J Vet Med Sci. 2000 Apr;62(4):453-5. doi: 10.1292/jvms.62.453.
Relationships among plasma renin activities (PRA), plasma angiotensin II (ATII) concentrations, atrial natriuretic peptide (ANP) concentrations and cardiopulmonary function values were examined in dogs with ascitic pulmonary heartworm disease and acute- and chronic-vena caval syndrome (CS). PRA, plasma ATII concentration and plasma ANP concentration tended to be higher or were significantly higher in dogs with ascites, acute- and chronic-CS. PRA correlated significantly with plasma ATII concentration, WBC count, ALP activity, plasma concentrations of urea nitrogen, creatinine, sodium, potassium, and chloride, right ventricular endodiastolic pressure and right atrial pressure. Plasma ATII concentration correlated significantly with WBC count, plasma concentrations of urea nitrogen, sodium, and potassium, right ventricular endodiastolic pressure and right atrial pressure. Plasma ANP concentration did not correlate with PRA or ATII concentration, but correlated significantly only with pulmonary arterial pressure.
在患有腹水型肺心丝虫病以及急慢性腔静脉综合征（CS）的犬中，研究了血浆肾素活性（PRA）、血浆血管紧张素II（ATII）浓度、心房利钠肽（ANP）浓度与心肺功能值之间的关系。患有腹水、急慢性CS的犬，其PRA、血浆ATII浓度和血浆ANP浓度往往较高或显著升高。PRA与血浆ATII浓度、白细胞计数、碱性磷酸酶活性、血浆尿素氮、肌酐、钠、钾和氯的浓度、右心室舒张末期压力及右心房压力显著相关。血浆ATII浓度与白细胞计数、血浆尿素氮、钠和钾的浓度、右心室舒张末期压力及右心房压力显著相关。血浆ANP浓度与PRA或ATII浓度无相关性，但仅与肺动脉压显著相关。
