麻风病中T淋巴细胞和CR+淋巴细胞概况及治疗效果
T and CR+ lymphocyte profile in leprosy and the effect of treatment.
作者信息
Sher R, Holm G, Kok S H, Koornhof H J, Glover A
出版信息
Infect Immun. 1976 Jan;13(1):31-5. doi: 10.1128/iai.13.1.31-35.1976.
Thymus-derived lymphocytes (T lymphocytes) and complement receptor-bearing lymphocytes (CR+ lymphocytes) were estimated by using erythrocyte rosettes and erythrocyte-antibody-complement rosettes as markers in untreated lepromatous and untreated tuberculoid patients and in healthy controls. Treated lepromatous cases were also investigated. Ten cases of untreated lepromatous patients were reassessed 6 months or more after therapy commenced. A significant decrease in both percentages and absolute numbers of CR+ cells in the untreated lepromatous leprosy subjects was observed. This decrease showed a return to normal levels after treatment. The percentage of T cells in the untreated lepromatous cases was normal; however, the absolute numbers of T cells and the total lymphocyte count showed a significant decrease. After therapy, the T cell population was unchanged but the total number of lymphocytes increased significantly with treatment. The absolute number of T and CR+ cells was significantly less in the untreated than in the treated lepromatous patients.
通过使用红细胞玫瑰花结和红细胞-抗体-补体玫瑰花结作为标志物，对未经治疗的瘤型麻风患者、未经治疗的结核样型患者以及健康对照者的胸腺衍生淋巴细胞（T淋巴细胞）和带有补体受体的淋巴细胞（CR+淋巴细胞）进行了评估。还对接受治疗的瘤型病例进行了调查。10例未经治疗的瘤型患者在治疗开始6个月或更长时间后进行了重新评估。在未经治疗的瘤型麻风患者中，观察到CR+细胞的百分比和绝对数量均显著下降。治疗后，这种下降显示恢复到正常水平。未经治疗的瘤型病例中T细胞的百分比正常；然而，T细胞的绝对数量和淋巴细胞总数显著下降。治疗后，T细胞群体未发生变化，但淋巴细胞总数随着治疗显著增加。未经治疗的瘤型患者中T细胞和CR+细胞的绝对数量明显少于接受治疗的瘤型患者。
Zotero 插件