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麻风病患者外周血中的胸腺依赖性淋巴细胞。

Thymus-dependent lymphocytes of peripheral blood in leprosy patients.

作者信息

Lim S D, Kiszkiss D F, Jacobson R R, Choi Y S, Good R A

出版信息

Infect Immun. 1974 Feb;9(2):394-9. doi: 10.1128/iai.9.2.394-399.1974.

DOI:10.1128/iai.9.2.394-399.1974
PMID:4544619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414815/
Abstract

Study of the numbers of thymus-derived lymphocytes by the rosette assay (T-RFC) in patients with leprosy reveals that lower than normal numbers of T-RFC are regularly seen in those patients with the active lepromatous form of this disease. Essentially normal numbers of T-RFC were found in inactive lepromatous, borderline, and indeterminate types of leprosy. The lowest percentages and lowest absolute numbers of T-RFC were encountered in patients with lepromatous leprosy resistant to chemotherapy. Patients with lepromatous leprosy complicated by erythema nodosum leprosum show numbers of T-RFC that are more nearly normal than the numbers of T-RFC in patients with uncomplicated lepromatous leprosy. These findings are discussed with respect to the pathogenesis of lepromatous leprosy and the T-RFC deficiency demonstrated in this disease. The possibility that transient defects in T-RFC numbers or function may predispose to lepromatous leprosy is proposed.

摘要

通过玫瑰花结试验（T-RFC）对麻风病患者胸腺来源淋巴细胞数量的研究表明，在这种疾病的活动性瘤型麻风患者中，经常可以看到T-RFC数量低于正常水平。在非活动性瘤型、界线类和未定类麻风患者中发现T-RFC数量基本正常。在对化疗耐药的瘤型麻风患者中，T-RFC的百分比和绝对数量最低。合并麻风结节性红斑的瘤型麻风患者的T-RFC数量比未合并瘤型麻风患者的T-RFC数量更接近正常水平。就瘤型麻风的发病机制以及该疾病中所显示的T-RFC缺乏进行了讨论。提出了T-RFC数量或功能的短暂缺陷可能易患瘤型麻风的可能性。

相似文献

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Thymus-dependent lymphocytes of peripheral blood in leprosy patients.麻风病患者外周血中的胸腺依赖性淋巴细胞。
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本文引用的文献

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The etiology of erythema nodosum leprosum.麻风结节性红斑的病因。
Int J Lepr Other Mycobact Dis. 1967 Jan-Mar;35(1):1-10.
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Studies on sulfone resistance in leprosy. I. Detection of cases.麻风病砜类耐药性研究。I. 病例检测。
Int J Lepr Other Mycobact Dis. 1966 Oct-Dec;34(4):375-90.
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Classification of leprosy according to immunity. A five-group system.根据免疫情况对麻风病进行分类。一种五组分类系统。
Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255-73.
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Phytohaemagglutinin-induced lymphocyte transformation in leprosy.植物血凝素诱导的麻风病淋巴细胞转化
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Rosette-formation between human lymphocytes and sheep red cells not involving immunoglobulin receptors.人淋巴细胞与绵羊红细胞之间不涉及免疫球蛋白受体的玫瑰花结形成。
Int Arch Allergy Appl Immunol. 1970;39(5-6):658-63. doi: 10.1159/000230390.
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Rosette formation by peripheral lymphocytes.外周淋巴细胞形成玫瑰花结。
Clin Exp Immunol. 1970 May;6(5):681-8.
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Transformation of lymphocytes by phytohemagglutinin in leprosy sera.
Int J Lepr Other Mycobact Dis. 1971 Jan-Mar;39(1):7-13.
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Production of macrophage inhibitory factor by patients with leprosy.麻风病患者巨噬细胞抑制因子的产生
Arch Dermatol. 1971 Apr;103(4):358-61.
9
Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response.麻风病免疫机制研究。3. 细胞和体液因素在体外免疫反应受损中的作用。
J Immunol. 1971 Apr;106(4):888-99.
10
Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients.植物血凝素和各种分枝杆菌抗原对麻风病患者淋巴细胞培养物的影响。
Proc Soc Exp Biol Med. 1968 Feb;127(2):391-5. doi: 10.3181/00379727-127-32698.

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