James S, Vorster H H, Venter C S, Kruger H S, Nell T A, Veldman F J, Ubbink J B
Department of Biological Sciences, University of North-West, Mmabatho, South Africa.
Thromb Res. 2000 Jun 1;98(5):383-94. doi: 10.1016/s0049-3848(00)00197-3.
Nutritional status and risk factors for chronic diseases, including plasma fibrinogen and its determinants, of Africans in the Northwest Province of South Africa, have been studied in a cross-sectional survey. A representative sample of 1854 "apparently healthy" African men and women volunteers aged 15 years and older was recruited from 37 randomly selected sites throughout the Province and stratified for level of urbanisation. Information was collected using validated and culture-sensitive questionnaires. Fasting blood samples were drawn, and all measurements were done with standardised methodology using appropriate equipment, procedures, and controls. Fibrinogen concentration was measured in citrated plasma with the method of Clauss, using the ACL200 automated system and the international fibrinogen standard. The results revealed a population with a high mean plasma fibrinogen (3.17+/-1.10 g/L for HIV-negative men and 3. 64+/-1.12 g/L for HIV-negative women). Factors known to influence plasma fibrinogen, such as age, gender, smoking habit, and physical activity, were also observed in this population. Young rural men and women had the lowest fibrinogen level. Nasal snuff taking and HIV infection did not influence fibrinogen concentration. Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Increases in fibrinogen were associated with significant increases in serum lipids. Both under- and overnutrition seem to be associated with high plasma fibrinogen. It is concluded that overall nutritional status, possibly in addition to specific nutrients (and foods), influences plasma fibrinogen.
在一项横断面调查中，对南非西北省非洲人的营养状况及包括血浆纤维蛋白原及其决定因素在内的慢性病风险因素进行了研究。从全省37个随机选取的地点招募了1854名年龄在15岁及以上的“看似健康”的非洲男性和女性志愿者作为代表性样本，并按城市化水平进行分层。使用经过验证且对文化敏感的问卷收集信息。采集空腹血样，所有测量均采用标准化方法，使用适当的设备、程序和对照。采用Clauss法，使用ACL200自动化系统和国际纤维蛋白原标准，在枸橼酸盐血浆中测量纤维蛋白原浓度。结果显示，该人群的血浆纤维蛋白原平均水平较高（HIV阴性男性为3.17±1.10 g/L，HIV阴性女性为3.64±1.12 g/L）。在该人群中还观察到了已知会影响血浆纤维蛋白原的因素，如年龄、性别、吸烟习惯和身体活动。年轻的农村男性和女性纤维蛋白原水平最低。吸鼻烟和感染HIV不影响纤维蛋白原浓度。多变量分析显示，较低的血浆纤维蛋白原与女性低至正常的体重指数相关，与男性和女性符合谨慎饮食指南的饮食摄入量相关（动物蛋白摄入量低；反式脂肪酸摄入量低，植物蛋白、膳食纤维、维生素E和铁摄入量高，饮食P/S比值高）。血浆纤维蛋白原处于较高四分位数的受试者铁、维生素E和维生素B6（女性）状态显著较低。纤维蛋白原增加与血清脂质显著增加相关。营养不足和营养过剩似乎都与高血浆纤维蛋白原有关。研究得出结论，总体营养状况，可能还包括特定营养素（和食物），会影响血浆纤维蛋白原。
