Vorster H H, Jerling J C, Steyn K, Badenhorst C J, Slazus W, Venter C S, Jooste P L, Bourne L T
Department of Nutrition, PU for CHE, Potchefstroom, South Africa.
Public Health Nutr. 1998 Sep;1(3):169-76. doi: 10.1079/phn19980026.
To describe the distribution of plasma fibrinogen and relationships with other risk factors for coronary heart disease (CHD) and stroke in the black population of the Cape Peninsula.
A cross-sectional survey of a stratified proportional sample of randomly selected black men and women.
Households in Gugulethu, Langa, Nyanga, New Crossroads, KTC, Old Crossroads and Khayelitsha in the Cape Peninsula, South Africa.
One subject per household (352 men and 447 women), aged 15-64 years, voluntarily participated. Visitors, pregnant, lactating, ill, mentally retarded and intoxicated subjects were excluded.
Mean fibrinogen (thrombin time coagulation method) of men and women were higher than published data for Europeans but slightly lower than values of black Americans. Women aged 45-54 years had the highest level (3.13+/-0.89 g l(-1)) and men aged 15-24 years had the lowest (2.13+/-0.88 g l(-1)). Fifteen per cent of the men and 12% of the women had a level greater than 1 standard deviation of the mean for their age group. Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. The correlations with BMI, serum lipoproteins, iron, ferritin, and GGT suggest that nutritional status and therefore diet influences plasma fibrinogen.
Relatively high fibrinogen levels, tending to cluster with other, including diet-related, risk factors for CHD and stroke, were observed in black South Africans. It is suggested that fibrinogen may contribute to the high stroke incidence of this population group.
描述开普敦半岛黑人人群血浆纤维蛋白原的分布情况及其与冠心病（CHD）和中风其他危险因素的关系。
对随机选取的黑人男性和女性进行分层比例抽样的横断面调查。
南非开普敦半岛古古莱图、朗加、尼扬加、新十字路口、KTC、旧十字路口和凯伊利沙的家庭。
每户一名研究对象（352名男性和447名女性），年龄在15 - 64岁之间，自愿参与。访客、孕妇、哺乳期妇女、患病者、智障者和醉酒者被排除。
男性和女性的平均纤维蛋白原（凝血酶时间凝固法）高于欧洲人公布的数据，但略低于美国黑人的值。45 - 54岁的女性纤维蛋白原水平最高（3.13±0.89 g l⁻¹），15 - 24岁的男性最低（2.13±0.88 g l⁻¹）。15%的男性和12%的女性纤维蛋白原水平高于其年龄组均值的1个标准差。单因素和多因素分析显示，纤维蛋白原与吸烟习惯、年龄、体重指数（BMI）、总胆固醇和低密度脂蛋白（LDL）胆固醇、甘油三酯、血压及白细胞计数呈显著正相关（P<0.05），与高密度脂蛋白（HDL）胆固醇、γ-谷氨酰转移酶（GGT）、血清铁和铁蛋白呈显著负相关。与BMI、血清脂蛋白、铁、铁蛋白和GGT的相关性表明营养状况及饮食会影响血浆纤维蛋白原。
在南非黑人中观察到相对较高的纤维蛋白原水平，且倾向于与冠心病和中风的其他危险因素（包括与饮食相关的因素）聚集。提示纤维蛋白原可能导致该人群中风发病率较高。
