Selmer I, Schindler M, Allen J P, Humphrey P P, Emson P C
Department of Neurobiology, The Babraham Institute, Babraham Hall, CB2 4EF, Cambridge, UK.
Regul Pept. 2000 Jun 30;90(1-3):1-18. doi: 10.1016/s0167-0115(00)00108-7.
It has long been considered that somatostatin acts as a neuromodulator in the mammalian central nervous system but its precise physiological roles remain elusive. Early studies to identify somatostatin-binding sites revealed a widespread heterogeneous pattern, especially in the CNS. More recently, a family of somatostatin receptors have been identified, of which five genes (sst(1-5)) have been cloned. In this review, we discuss current data describing the localisation of the five receptor types. Recent progress in understanding their function has been made using high-affinity, selective receptor ligands and transgenic animal technology. Finally, the therapeutic potential for somatostatin receptor-selective compounds as analgesics is considered.
长期以来，人们一直认为生长抑素在哺乳动物中枢神经系统中起神经调质的作用，但其确切的生理作用仍不清楚。早期鉴定生长抑素结合位点的研究揭示了一种广泛的异质性模式，尤其是在中枢神经系统中。最近，已鉴定出一个生长抑素受体家族，其中五个基因（sst(1 - 5)）已被克隆。在这篇综述中，我们讨论了描述这五种受体类型定位的当前数据。利用高亲和力、选择性受体配体和转基因动物技术，在理解它们的功能方面取得了最新进展。最后，考虑了生长抑素受体选择性化合物作为镇痛药的治疗潜力。
