Anderson J W, Davidson M H, Blonde L, Brown W V, Howard W J, Ginsberg H, Allgood L D, Weingand K W
University of Kentucky and the Veterans Affairs Medical Center, Lexington, KY 40511, USA.
Am J Clin Nutr. 2000 Jun;71(6):1433-8. doi: 10.1093/ajcn/71.6.1433.
Hypercholesterolemia is a major risk factor for coronary heart disease and nutrition management is the initial therapeutic approach.
This multicenter study evaluated the long-term effectiveness of psyllium husk fiber as an adjunct to diet in the treatment of persons with primary hypercholesterolemia.
Men and women with hypercholesterolemia were recruited. After following an American Heart Association Step I diet for 8 wk (dietary adaptation phase), eligible subjects with serum LDL-cholesterol concentrations between 3.36 and 4.91 mmol/L were randomly assigned to receive either 5.1 g psyllium or a cellulose placebo twice daily for 26 wk while continuing diet therapy.
Serum total and LDL-cholesterol concentrations were 4.7% and 6.7% lower in the psyllium group than in the placebo group after 24-26 wk (P < 0.001). Other outcome measures did not differ significantly between groups.
Treatment with 5.1 g psyllium twice daily produces significant net reductions in serum total and LDL-cholesterol concentrations in men and women with primary hypercholesterolemia. Psyllium therapy is an effective adjunct to diet therapy and may provide an alternative to drug therapy for some patients.
高胆固醇血症是冠心病的主要危险因素，营养管理是初始治疗方法。
这项多中心研究评估了车前子壳纤维作为饮食辅助手段治疗原发性高胆固醇血症患者的长期疗效。
招募高胆固醇血症的男性和女性。在遵循美国心脏协会一级饮食8周（饮食适应阶段）后，血清低密度脂蛋白胆固醇浓度在3.36至4.91 mmol/L之间的符合条件的受试者被随机分配，每天两次接受5.1克车前子壳或纤维素安慰剂，持续26周，同时继续饮食治疗。
24至26周后，车前子壳组的血清总胆固醇和低密度脂蛋白胆固醇浓度比安慰剂组分别低4.7%和6.7%（P < 0.001）。其他结果指标在两组之间没有显著差异。
每天两次服用5.1克车前子壳可使原发性高胆固醇血症的男性和女性血清总胆固醇和低密度脂蛋白胆固醇浓度显著净降低。车前子壳疗法是饮食疗法的有效辅助手段，可能为一些患者提供药物治疗的替代方案。
