• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effects of physicochemical properties and other factors on systemic nasal drug delivery.

作者信息

Romeo VD, deMeireles J, Sileno AP, Pimplaskar HK, Behl CR

机构信息

Nastech Pharmaceutical Company, Inc., 45 Davids Drive, Hauppauge, NY 11788, USA

出版信息

Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):89-116. doi: 10.1016/s0169-409x(97)00063-x.

DOI:10.1016/s0169-409x(97)00063-x
PMID:10837582
Abstract
摘要

相似文献

1
Effects of physicochemical properties and other factors on systemic nasal drug delivery.物理化学性质及其他因素对鼻腔全身给药的影响。
Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):89-116. doi: 10.1016/s0169-409x(97)00063-x.
2
Challenges in nasal drug absorption: how far have we come?鼻腔给药吸收面临的挑战：我们取得了多大进展？
Ther Deliv. 2016 Jul;7(7):495-510. doi: 10.4155/tde-2016-0022.
3
Nasal-nanotechnology: revolution for efficient therapeutics delivery.鼻腔纳米技术：高效治疗药物输送的革命。
Drug Deliv. 2016;23(3):681-93. doi: 10.3109/10717544.2014.920431. Epub 2014 Jun 5.
4
Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs.通过鼻腔给药左旋多巴的水溶性前药来增强其全身和中枢神经系统的特异性递送。
Pharm Res. 2000 Aug;17(8):978-84. doi: 10.1023/a:1007583422634.
5
Intranasal drug delivery: an efficient and non-invasive route for systemic administration: focus on opioids.鼻腔内药物输送：一种高效且非侵入性的全身给药途径：以阿片类药物为重点。
Pharmacol Ther. 2012 Jun;134(3):366-79. doi: 10.1016/j.pharmthera.2012.03.003. Epub 2012 Mar 23.
6
Overview of intranasally delivered peptides: key considerations for pharmaceutical development.鼻腔内递呈肽类药物：药物开发的关键考量因素。
Expert Opin Drug Deliv. 2018 Oct;15(10):991-1005. doi: 10.1080/17425247.2018.1517742. Epub 2018 Sep 19.
7
The nasal delivery of nanoencapsulated statins - an approach for brain delivery.纳米包封他汀类药物的鼻腔给药——一种脑内给药途径。
Int J Nanomedicine. 2016 Dec 7;11:6575-6590. doi: 10.2147/IJN.S119033. eCollection 2016.
8
Cyclodextrins in nasal drug delivery.环糊精在鼻腔给药中的应用
Adv Drug Deliv Rev. 1999 Mar 1;36(1):41-57. doi: 10.1016/s0169-409x(98)00054-4.
9
Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery.物理化学性质对用于基因递送的非病毒载体药代动力学的影响。
J Drug Target. 2002 Mar;10(2):99-104. doi: 10.1080/10611860290016694.
10
Physicochemical and physiological considerations for efficient nose-to-brain targeting.用于提高脑靶向效率的物理化学和生理学考虑因素。
Expert Opin Drug Deliv. 2012 Jan;9(1):19-31. doi: 10.1517/17425247.2012.636801. Epub 2011 Dec 16.

引用本文的文献

1
Nose-to-brain drug delivery: from bench to bedside.鼻-脑给药：从实验台到病床边
Transl Neurodegener. 2025 May 19;14(1):23. doi: 10.1186/s40035-025-00481-w.
2
Investigation of a Thermoresponsive In Situ Hydrogel Loaded with Nanotriphala: Implications for Antioxidant, Anti-Inflammatory, and Antimicrobial Therapy in Nasal Disorders.载有纳米三果木的热敏原位水凝胶的研究：对鼻腔疾病抗氧化、抗炎和抗菌治疗的意义。
Gels. 2025 Feb 2;11(2):106. doi: 10.3390/gels11020106.
3
Systematic review of peptide nanoparticles for improved diabetes outcomes: insights and opportunities.
用于改善糖尿病结局的肽纳米颗粒的系统评价：见解与机遇
Discov Nano. 2025 Feb 17;20(1):41. doi: 10.1186/s11671-025-04215-9.
4
Intranasal delivery of imaging agents to the brain.经鼻腔向脑部递送成像剂。
Theranostics. 2024 Aug 19;14(13):5022-5101. doi: 10.7150/thno.98473. eCollection 2024.
5
In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using Intranasal Route.经鼻给药递药于脑的深入机制、挑战和机遇
AAPS PharmSciTech. 2024 May 6;25(5):96. doi: 10.1208/s12249-024-02810-0.
6
Advances in Aerosol Formulation for Targeted Delivery of Therapeutic Agents from Nose to Brain.用于将治疗剂从鼻腔靶向递送至脑部的气雾剂制剂的进展。
Curr Drug Deliv. 2025;22(6):678-693. doi: 10.2174/0115672018285350240227073607.
7
Lamotrigine-Loaded Poloxamer-Based Thermo-Responsive Sol-Gel: Formulation, In Vitro Assessment, Ex Vivo Permeation, and Toxicology Study.基于泊洛沙姆的载拉莫三嗪热响应性溶胶-凝胶：制剂、体外评估、离体渗透及毒理学研究。
Gels. 2023 Oct 14;9(10):817. doi: 10.3390/gels9100817.
8
The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease.垂体腺苷酸环化酶激活肽经鼻至脑递送治疗神经元疾病的潜力
Pharmaceutics. 2023 Jul 28;15(8):2032. doi: 10.3390/pharmaceutics15082032.
9
Thermoreversible Gel Formulation for the Intranasal Delivery of Salmon Calcitonin and Comparison Studies of Bioavailability.用于鲑鱼降钙素鼻腔给药的热可逆凝胶制剂及其生物利用度比较研究
Turk J Pharm Sci. 2023 Jul 7;20(3):127-140. doi: 10.4274/tjps.galenos.2022.09482.
10
Challenges in the Development and Application of Organ-on-Chips for Intranasal Drug Delivery Studies.用于鼻内给药研究的器官芯片开发与应用中的挑战。
Pharmaceutics. 2023 May 22;15(5):1557. doi: 10.3390/pharmaceutics15051557.