Malik S, Roeder R G
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA.
Trends Biochem Sci. 2000 Jun;25(6):277-83. doi: 10.1016/s0968-0004(00)01596-6.
A novel multiprotein complex has recently been identified as a coactivator for transcriptional control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits.
最近，一种新型多蛋白复合物被鉴定为高等真核细胞中RNA聚合酶II对蛋白质编码基因转录控制的共激活因子。该复合物在进化上与酵母中的中介体复合物相关，基于其结构和功能特征，有望成为多种调控回路的关键靶点。
