Allen J C, Sheremata W, Cosgrove J B, Osterland K, Shea M
Neurology. 1976 Jun;26(6 PT 1):579-83. doi: 10.1212/wnl.26.6.579.
Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cell is largest in the acute stage of a relapse (65 percent) and diminishes by the second week (41 percent). Conversely, the stable patients had a lower percentage of T cells (30 percent) and a relatively high percentage of nonreacting cells (66 percent). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.
在21例复发型多发性硬化症患者和10例稳定型多发性硬化症患者中，对脑脊液中的T淋巴细胞群和B淋巴细胞群进行了鉴定。结果表明，复发急性期T细胞的百分比最高（65%），到第二周时会下降（41%）。相反，稳定型患者的T细胞百分比更低（30%），而非反应性细胞的百分比相对较高（66%）。脑脊液中T细胞的比例与该疾病的临床活动呈正相关，这进一步表明细胞免疫机制在多发性硬化症的发病机制中起作用。
