Collins R L, Turner R A, Johnson A M, Whitley N O, McLean R L
Arthritis Rheum. 1976 May-Jun;19(3):623-8. doi: 10.1002/art.1780190316.
Twenty-six of 43 patients (60.5%) with classic rheumatoid arthritis (RA) participating in a controlled, prospective study were found to have maximal midexpiratory flow rates (MMEFs) suggestive of obstructive pulmonary disease. Cigarette smokers with RA had significantly lower MMEFs than either nonsmokers with RA or smokers with degenerative joint disease. There was an increased prevalence of the Pi phenotype MS among the RA patients. Interstitial fibrosis, tobacco smoking, and protease inhibitor deficiencies were all significant factors in producing airway obstruction in patients with RA.
在一项对照性前瞻性研究中，43例典型类风湿关节炎（RA）患者中有26例（60.5%）的最大呼气中期流速（MMEF）提示存在阻塞性肺疾病。患RA的吸烟者的MMEF显著低于患RA的非吸烟者或患退行性关节病的吸烟者。RA患者中Pi表型MS的患病率有所增加。间质性纤维化、吸烟和蛋白酶抑制剂缺乏都是导致RA患者气道阻塞的重要因素。
