Thumboo J, Fong K Y, Chan S P, Leong K H, Feng P H, Thio S T, Boey M L
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
J Rheumatol. 2000 Jun;27(6):1414-20.
To prospectively identify factors influencing quality of life (QOL) over 6 months in patients with systemic lupus erythematosus (SLE).
Ninety ethnically diverse patients with SLE completed questionnaires administered 6 months apart assessing QOL (using the Medical Outcomes Study Short Form-36) and demographic, socioeconomic, psychosocial, and behavioral factors. Disease activity, damage, and treatment were recorded at both evaluations. Multiple linear regression (adjusting for baseline health status) was used to identify factors influencing mental and physical health.
Improved physical health after 6 months was associated with reductions in learned helplessness (p = 0.034), improved mental health (p<0.001), longer disease duration (p = 0.009), and better physical health at baseline (p = 0.027). Improved mental health after 6 months was associated with better family support (p = 0.002), improvements in physical health (p<0.001), disease activity, and prednisolone dose (interaction term p = 0.019), less disease related damage (p<0.001), non-use of cytotoxic drugs (p = 0.02), and older age at diagnosis (p = 0.007).
Potentially modifiable psychosocial, disease, and therapy related factors influence QOL in patients with SLE.
前瞻性地确定影响系统性红斑狼疮（SLE）患者6个月以上生活质量（QOL）的因素。
90名不同种族的SLE患者完成了相隔6个月进行的问卷调查，评估生活质量（使用医学结局研究简表36）以及人口统计学、社会经济、心理社会和行为因素。在两次评估中均记录疾病活动、损伤和治疗情况。采用多元线性回归（调整基线健康状况）来确定影响心理健康和身体健康的因素。
6个月后身体健康状况改善与习得性无助感降低（p = 0.034）、心理健康改善（p<0.001）、病程延长（p = 0.009）以及基线时身体健康状况较好（p = 0.027）相关。6个月后心理健康改善与更好的家庭支持（p = 0.002）、身体健康改善（p<0.001）、疾病活动度和泼尼松龙剂量（交互项p = 0.019）、较少的疾病相关损伤（p<0.001）、未使用细胞毒性药物（p = 0.02）以及诊断时年龄较大（p = 0.007）相关。
潜在可改变的心理社会、疾病和治疗相关因素会影响SLE患者的生活质量。
