意大利系统性红斑狼疮患者的健康相关生活质量。I. 身体和心理维度之间的关系以及年龄的影响。

Health-related quality of life in Italian patients with systemic lupus erythematosus. I. Relationship between physical and mental dimension and impact of age.

作者信息

Rinaldi S, Doria A, Salaffi F, Ermani M, Iaccarino L, Ghirardello A, Zampieri S, Sarzi-Puttini P, Gambari P F, Perini G

机构信息

Cattedra e Divisione di Reumatologia, Dipartimento di Scienze Mediche e Chirurgiche, Via Giustiniani 2, 35128 Padua, Italy.

出版信息

Rheumatology (Oxford). 2004 Dec;43(12):1574-9. doi: 10.1093/rheumatology/keh397. Epub 2004 Sep 7.

DOI:10.1093/rheumatology/keh397

PMID:15353611

Abstract

OBJECTIVE

To examine health-related quality of life (HRQOL) in Italian patients with systemic lupus erythematosus (SLE) and compare it with that of healthy people, and to investigate relationships among different dimensions and subscales of a generic health status measure.

METHODS

The Medical Outcomes Study Short Form-36 (SF-36) was applied in a cohort of 126 consecutive SLE patients and 96 healthy controls. At the time of HRQOL testing, all patients underwent clinical and laboratory evaluation.

RESULTS

Both physical (PCS) and mental (MCS) component summary scores of the SF-36 were reduced in patients compared with controls. In SLE great variability in all the subscales was observed. Significant correlations between PCS and MCS and between many different subscales were observed in patients but not in controls. The PCS was higher than MCS more frequently in controls than in SLE patients (81 vs 48.4%, P<0.00001). In SLE, HRQOL tended to worsen with age.

CONCLUSION

Both PCS and MCS contribute to the decrease in HRQOL in SLE patients. In SLE the mutual interaction between these two dimensions seems to be more relevant than in healthy people.

摘要

目的

研究意大利系统性红斑狼疮（SLE）患者的健康相关生活质量（HRQOL），并与健康人群进行比较，同时探讨一般健康状况测量的不同维度和子量表之间的关系。

方法

对126例连续的SLE患者和96例健康对照者应用医学结局研究简明健康调查问卷（SF-36）。在进行HRQOL测试时，所有患者均接受临床和实验室评估。

结果

与对照组相比，SLE患者的SF-36身体（PCS）和心理（MCS）成分总结得分均降低。在SLE患者中，所有子量表均存在很大差异。患者中观察到PCS与MCS以及许多不同子量表之间存在显著相关性，而对照组中未观察到。与SLE患者相比，对照组中PCS高于MCS的频率更高（81%对48.4%，P<0.00001）。在SLE患者中，HRQOL往往随年龄增长而恶化。