正常人血清中的“隐匿性”IgG抗球蛋白
Hidden' IgG antiglobulins in normal human serum.
作者信息
Hay F C, Nineham L J, Torrigiani G, Roitt I M
出版信息
Clin Exp Immunol. 1976 Aug;25(2):185-90.
Abstract
Hidden antiglobulins reacting with whole rabbit immunoglobulin were found by radioassay or indirect haemagglutination after gel filtration or ultracentrifugation of normal serum. Suprisingly, both the IgM and IgG antiglobulins were present in the same macroglobulin fractions. The IgG antiglobulins could be dissociated into 7S components by separating the serum under acid conditions. Antiglobulin activity was a function of the Fab region.
摘要
通过对正常血清进行凝胶过滤或超速离心后，采用放射测定法或间接血凝试验发现了与全兔免疫球蛋白发生反应的隐蔽抗球蛋白。令人惊讶的是，IgM和IgG抗球蛋白都存在于相同的巨球蛋白组分中。在酸性条件下分离血清，IgG抗球蛋白可解离为7S成分。抗球蛋白活性是Fab区的一种功能。
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2
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J Exp Med. 1965 Jul 1;122(1):181-93. doi: 10.1084/jem.122.1.181.
3
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Vox Sang. 1963 Mar-Apr;8:133-52. doi: 10.1111/j.1423-0410.1963.tb03290.x.
4
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J Clin Invest. 1961 Jan;40(1):117-29. doi: 10.1172/JCI104224.
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