辅助性T细胞动力学及早期和记忆性辅助性T细胞上抗原受体表达的研究
Helper T-cell kinetics and investigation of antigen receptor expression on early and memory T-helper cells.
作者信息
Mohr R, Krawinkel U
出版信息
Immunology. 1976 Aug;31(2):249-55.
Abstract
The subcutaneous application of soluble antigen resulted in generation of helper T lymphocytes in the draining lymph nodes, tested 4 days after priming in the adoptive transfer system. Four days later a specific helper T-cell population was detected in the spleen. B-cell activity could be demonstrated 4-5 days after helper T-cell activity in both organs. We investigated the early helper T-cell population and memory T cells with respect to differences in the expression of antigen receptors. No such differences could be detected, either by anti-immunoglobulin-coated Degalan columns or by an antigen-specific rosetting method.
摘要
在过继转移系统中，初次免疫4天后检测发现，可溶性抗原皮下注射可使引流淋巴结中产生辅助性T淋巴细胞。4天后，在脾脏中检测到特异性辅助性T细胞群。在这两个器官中，辅助性T细胞活性出现4 - 5天后可证明B细胞活性。我们研究了早期辅助性T细胞群和记忆T细胞在抗原受体表达方面的差异。无论是通过抗免疫球蛋白包被的德加兰柱还是通过抗原特异性花环法，均未检测到此类差异。
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