B细胞记忆的早期动力学及T细胞对体外表达的影响。
Early kinetics of B cell memory and the influence of T cells on the expression in vitro.
作者信息
Kraal G, Boden D
出版信息
Z Immunitatsforsch Immunobiol. 1977 Sep;153(3):226-35.
PMID:303841
Abstract
To study the early kinetics of B cell memory to sheep erythrocytes mouse spleen cells were cultured after short priming times in vivo. The influence of T cells on the expression of memory in vitro was investigated by treatment with anti-theta serum. Within 48 hours of in vivo priming part of the B cell population can differentiate into cells capable of IgG production after secondary antigen contact in vitro without the help of T cells. The presence of antigen was required for the in vitro development.
摘要
为研究B细胞对绵羊红细胞的早期记忆动力学，在体内进行短时间致敏后培养小鼠脾细胞。通过用抗θ血清处理来研究T细胞对体外记忆表达的影响。在体内致敏48小时内，部分B细胞群体在体外再次接触抗原后，无需T细胞帮助就能分化为能够产生IgG的细胞。体外发育需要有抗原存在。
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