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罗森-帕尔病毒对小鼠的免疫抑制作用;感染后脾脏和淋巴结细胞的淋巴细胞标志物及帽化反应

Immunodepression by Rowson-Parr virus in mice; lymphocyte markers and capping response of spleen and lymph node cells after infection.

作者信息

Bendinelli M, Friedman H

出版信息

Infect Immun. 1976 Sep;14(3):613-7. doi: 10.1128/iai.14.3.613-617.1976.

Abstract

Infection with Rowson-Parr virus (RPV) induced a rapid reduction in the number of immunoglobulin-positive and theta antigen-positive cells detectable by immunofluorescence in the spleens of susceptible BALB/c mice. The changes produced by RPV infection in the lymph nodes were different, since the number of immunoglobulin-positive cells was increased and the proportion of theta-positive cells remained unchanged. However, the ability of immunoglobulin-bearing cells to redistribute their receptors into caps was reduced in both types of lymphoid tissue. A similar pattern of changes was produced by infection with Friend leukemia complex, from which RPV was originally obtained. These effects of RPV and Friend leukemia complex may contribute to the immunodepressed state of infected mice.

摘要

罗森 - 帕尔病毒(RPV)感染导致易感的BALB/c小鼠脾脏中通过免疫荧光可检测到的免疫球蛋白阳性和θ抗原阳性细胞数量迅速减少。RPV感染在淋巴结中产生的变化不同,因为免疫球蛋白阳性细胞数量增加,而θ阳性细胞的比例保持不变。然而,在两种淋巴组织中,携带免疫球蛋白的细胞将其受体重新分布到帽中的能力均降低。最初从其中获得RPV的弗瑞德白血病复合体感染也产生了类似的变化模式。RPV和弗瑞德白血病复合体的这些作用可能导致感染小鼠的免疫抑制状态。

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