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罗森-帕尔病毒对小鼠的免疫抑制作用。I. 罗森-帕尔病毒的生长曲线及其与弗氏病毒的免疫关系。

Immunodepression by Rowson-Parr virus in mice. I. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus.

作者信息

Bendinelli M, Nardini L

出版信息

Infect Immun. 1973 Feb;7(2):152-9. doi: 10.1128/iai.7.2.152-159.1973.

Abstract

The growth curve of Rowson-Parr virus (RPV) was studied in the spleen of mice infected with RPV only and of mice infected with Friend virus (FV) preparations, which consist of a mixture of RPV and FV. In mice infected with FV preparations, RPV replicated to a higher titer than FV and attained higher levels than in singly infected mice. The chronic viremia of RPV-infected mice was found to coexist with circulating anti-RPV antibodies. These antibodies also neutralize FV and are probably responsible for the resistance against FV conferred to mice by prior infection with RPV.

摘要

研究了罗森 - 帕尔病毒(RPV)在仅感染RPV的小鼠脾脏以及感染弗瑞德病毒(FV)制剂(由RPV和FV混合物组成)的小鼠脾脏中的生长曲线。在感染FV制剂的小鼠中,RPV复制到比FV更高的滴度,且达到比单独感染小鼠更高的水平。发现感染RPV的小鼠的慢性病毒血症与循环抗RPV抗体共存。这些抗体也能中和FV,可能是先前感染RPV赋予小鼠抗FV抵抗力的原因。

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