Norden C W, Feldman H A
J Clin Microbiol. 1976 Aug;2(2):136-8.
Bactericidal and radioimmunoassay (RIA) antibodies to Hemophilus influenzae, type b, were measured in the sera of 85 children aged 18 through 71 months. Bactericidal antibodies were present in only 21% of those over 60 months; RIA levels rose linearly with increasing age (P less than 0.005). Bactericidal antibodies were present in nine of 29 sera with RIA levels greater than or equal to 0.7 mug/ml and in only four of 56 sera with RIA levels less than 0.7 mug/ml (P less than 0.01). The discrepancies between the two tests probably reflect their measurement of different antibodies. Results of the RIA fit the clinical observation that H. influenzae meningitis becomes less frequent with age.
检测了85名年龄在18至71个月的儿童血清中针对b型流感嗜血杆菌的杀菌抗体和放射免疫测定（RIA）抗体。60个月以上儿童中仅有21%存在杀菌抗体；RIA水平随年龄增长呈线性上升（P<0.005）。在RIA水平大于或等于0.7微克/毫升的29份血清中有9份存在杀菌抗体，而在RIA水平低于0.7微克/毫升的56份血清中仅有4份存在杀菌抗体（P<0.01）。两种检测方法之间的差异可能反映了它们所检测的抗体不同。RIA的结果符合流感嗜血杆菌脑膜炎随年龄增长发病率降低这一临床观察结果。
