De Gast G C, Houwen B, van der Hem G K, The T H
Infect Immun. 1976 Nov;14(5):1138-43. doi: 10.1128/iai.14.5.1138-1143.1976.
To study the relation between general cellular immunity and the course of hepatitis B within a group of chronic hemodialysis patients, T-lymphocyte number and function were investigated in 13 persistently hepatitis B surface antigen (HBSAg)-positive patients, in 32 HBSAg-negative patients, and in 11 patients who had recovered from hepatitis B and compared with that of 21 age-matched controls. Phytohemagglutinin-induced lymphocyte stimulation in vitro and the number of circulating T-cells in the HBSAg-positive group were significantly decreased as compared with those of the recovered group and the controls. Lymphocyte stimulation by pokeweed mitogen and by an antigen cocktail showed the same tendency, but no significant differences between the HBSAg-positive and the recovered groups. Uremic sera from the three patient groups had similar depressive effects on phytohemagglutinin induced lymphocyte stimulation of controls. Serum immunoglobulin G, (IgG), IgA, and IgM were normal in the three patient groups. It is concluded that chronic hemodialysis patients, who have become persistent HBSAg-carriers, have a significantly decreased T-lymphocyte number and function as compared with hemodialysis patients who are able to eliminat hepatitis B virus (HBV). The difference could not be ascribed to the HBV infection itself. This indicates that T-cells play an important role in the elimination of HBV in hemodialysis patients.
为研究一组慢性血液透析患者的一般细胞免疫与乙肝病程之间的关系，对13例乙肝表面抗原（HBSAg）持续阳性患者、32例HBSAg阴性患者以及11例已从乙肝中康复的患者进行了T淋巴细胞数量和功能的调查，并与21名年龄匹配的对照组进行了比较。与康复组和对照组相比，HBSAg阳性组中植物血凝素诱导的体外淋巴细胞刺激以及循环T细胞数量显著降低。商陆有丝分裂原和抗原混合物诱导的淋巴细胞刺激也显示出相同趋势，但HBSAg阳性组与康复组之间无显著差异。三个患者组的尿毒症血清对植物血凝素诱导的对照组淋巴细胞刺激具有相似的抑制作用。三个患者组的血清免疫球蛋白G（IgG）、IgA和IgM均正常。得出的结论是，与能够清除乙肝病毒（HBV）的血液透析患者相比，成为HBSAg持续携带者的慢性血液透析患者的T淋巴细胞数量和功能显著降低。这种差异不能归因于HBV感染本身。这表明T细胞在血液透析患者清除HBV中起重要作用。
