Saiki I
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Biol Pharm Bull. 2000 Jun;23(6):677-88. doi: 10.1248/bpb.23.677.
Juzen-taiho-to is a Kampo (Japanese and Chinese traditional) medicine, and is a nourishing agent, a so-called "Hozai" (in Japanese), that is used for improving disturbances and imbalances in the homeostatic condition of the body. This drug is administered to patients in various weakened conditions, including post-surgery patients and patients with chronic illnesses, where it can alleviate general symptoms such as extreme fatigue, pale complexion, loss of appetite, dry or scaly skin, night sweating, and dryness of the mouth. Currently, Juzen-taiho-to is often administered to cancer patients, and has been shown to possess various biological activities, such as enhancement of phagocytosis, cytokine induction, antibody production, induction of the mitogenic activity of spleen cells, anti-tumor effects when combined with surgical excision, anti-tumor effects with or without other drugs, and protection against the deleterious effects of anti-cancer drugs as well as radiation-induced immunosuppression and bone marrow toxicity. This article focuses on the antitumor and antimetastatic properties of Kampo formulations and describes the effect of Juzen-taiho-to and related formulations on tumor development, progression and metastasis in vivo. We also discuss the mechanism of the inhibitory action and the importance of the formulation and the constituent drugs in determining the efficacy.
十全大补汤是一种汉方（日本和中国传统）药，是一种滋补剂，即所谓的“补剂”（日语），用于改善身体内稳态状况的紊乱和失衡。这种药物被用于各种身体虚弱的患者，包括术后患者和慢性病患者，在这些患者中它可以缓解诸如极度疲劳、面色苍白、食欲不振、皮肤干燥或有鳞屑、盗汗以及口干等一般症状。目前，十全大补汤经常被用于癌症患者，并已显示出具有多种生物学活性，如增强吞噬作用、诱导细胞因子、产生抗体、诱导脾细胞的有丝分裂活性、与手术切除联合时的抗肿瘤作用、无论有无其他药物时的抗肿瘤作用，以及对抗癌药物的有害作用以及辐射诱导的免疫抑制和骨髓毒性的保护作用。本文重点关注汉方制剂的抗肿瘤和抗转移特性，并描述十全大补汤及相关制剂对体内肿瘤发生、进展和转移的影响。我们还讨论了抑制作用的机制以及制剂和组成药物在确定疗效方面的重要性。
