Hirono N, Mega M S, Dinov I D, Mishkin F, Cummings J L
Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji 670-0981, Japan.
Arch Neurol. 2000 Jun;57(6):861-6. doi: 10.1001/archneur.57.6.861.
Aggressive behavior is common in patients with dementia. Temporolimbic and prefrontal cortical lesions can produce pathological aggression; however, involvement of these structures has not been established in aggressive patients with dementia.
To study the relation between regional brain perfusion and aggressive behavior in patients with dementia.
We compared the pattern of regional cerebral perfusion determined with technetium Tc 99m-labeled hexamethylpropelene amineoxime single photon emission computed tomography in 2 groups of 10 patients with dementia with and without aggression, that were comparable for demographic factors, severity of cognitive impairments, and other behavioral symptoms as measured by the Neuropsychiatric Inventory.
Patients with aggression revealed significant (P<.001) hypoperfusion in the left anterior temporal cortex; additional bilateral dorsofrontal and right parietal cortex were also found to be significantly hypoperfused.
These results indicated an association between aggression and decreased perfusion in the left anterior temporal cortex. Arch Neurol. 2000.
攻击性行为在痴呆患者中很常见。颞叶边缘和前额叶皮质病变可导致病理性攻击行为；然而，在有攻击行为的痴呆患者中，这些结构的受累情况尚未得到证实。
研究痴呆患者脑局部灌注与攻击行为之间的关系。
我们比较了两组各10例有或无攻击行为的痴呆患者的脑局部灌注模式，这两组患者在人口统计学因素、认知障碍严重程度以及通过神经精神量表测量的其他行为症状方面具有可比性，采用锝Tc 99m标记的六甲丙二胺肟单光子发射计算机断层扫描来确定脑局部灌注情况。
有攻击行为的患者在左侧颞叶前部皮质显示出显著（P<.001）灌注不足；还发现双侧背侧额叶和右侧顶叶皮质也有明显的灌注不足。
这些结果表明攻击行为与左侧颞叶前部皮质灌注减少之间存在关联。《神经病学档案》。2000年。
