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共价抗原-抗体复合物的免疫调节作用。III. 相对于非T细胞依赖性抗原，根据复合物给药时间的不同而产生的增强或抑制作用。

Immunoregulatory effects of covalent antigen-antibody complexes. III. Enhancement or suppression depending on the time of administration of complex relative to a T-independent antigen.

作者信息

Tite J P, Morrison C A, Taylor R B

出版信息

Immunology. 1981 Feb;42(2):355-62.

PMID:7007223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458085/
Abstract

The photosensitive affinity label NAP (4-azido-2-nitrophenyl) was used to make a stable covalent-bonded monomeric immune complex (Ag2Ab) between rabbit anti-NAP antibody and a bihaptenic compound containing NAP linked to fluorescein (NAP-aminocaproyl-lysyl-Fl). This complex injected into mice had marked effects on their subsequent response to fluorescein coupled to a thymus-independent carrier (Fl-ficoll). Depending on the time at which the complex was administered relative to challenge, it was possible to obtain either enhancing or suppressive effects. The enhancing but not the suppressive effect of complex was dependent on immune recognition of the rabbit IgG carrier. While the suppressive effect probably results from complex-mediated inactivation of T-independent B cells, it is suggested that the enhancing effect results from priming of the T-dependent B cells by Fl-Ficoll followed by their triggering into antibody production by rabbit IgG-specific helper cells.

摘要

使用光敏亲和标记物 NAP（4-叠氮基-2-硝基苯基）在兔抗 NAP 抗体与一种含有与荧光素相连的 NAP 的双半抗原化合物（NAP-氨基己酰-赖氨酰-Fl）之间形成稳定的共价结合单体免疫复合物（Ag2Ab）。将这种复合物注射到小鼠体内，对它们随后对与胸腺非依赖性载体偶联的荧光素（Fl-菲可）的反应产生显著影响。根据复合物给药时间相对于攻击时间的不同，有可能获得增强或抑制作用。复合物的增强作用而非抑制作用依赖于对兔 IgG 载体的免疫识别。虽然抑制作用可能是由复合物介导的胸腺非依赖性 B 细胞失活导致的，但有人认为增强作用是由 Fl-菲可引发依赖性 B 细胞，随后由兔 IgG 特异性辅助细胞触发其产生抗体所致。

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Bovine milk IgG, but not serum IgG, inhibits pokeweed mitogen-induced antibody secretion by human peripheral blood mononuclear cells.牛乳IgG可抑制商陆丝裂原诱导的人外周血单个核细胞的抗体分泌，但血清IgG则无此作用。
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本文引用的文献

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B cell tolerance induced by polymeric antigens. III. Dissociation of antibody formation and memory generation in tolerant mice.多聚抗原诱导的B细胞耐受性。III. 耐受性小鼠中抗体形成与记忆产生的解离
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Regulatory effect of antibody on the immune response.抗体对免疫反应的调节作用。
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DNP-Lys-ficoll: a T-independent antigen which elicits both IgM and IgG anti-DNP antibody-secreting cells.二硝基苯赖氨酸-聚蔗糖：一种非T细胞依赖性抗原，可引发分泌IgM和IgG抗二硝基苯抗体的细胞。
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The immunological properties of haptens coupled to thymus-independent carrier molecules. IV. The IgG response to dinitrophenylated Ficoll.与非胸腺依赖性载体分子偶联的半抗原的免疫学特性。IV. 对二硝基苯基化聚蔗糖的IgG反应
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Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.对T细胞依赖性和T细胞非依赖性抗原产生反应的小鼠B细胞亚群。
J Exp Med. 1976 Aug 1;144(2):382-97. doi: 10.1084/jem.144.2.382.
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Immunoregulatory effects of a covalent antigen-antibody complex.共价抗原-抗体复合物的免疫调节作用
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Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory.B细胞记忆的研究。II. 非T细胞依赖性抗原可诱导B细胞记忆。
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Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors.免疫复合物对抗原反应性B淋巴细胞的直接阻断。抗原与Fc受体的连接为产生IgM的细胞前体提供的“关闭”信号。
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Differential tolerance of thymus-independent and thymus-dependent antibody responses.非胸腺依赖性和胸腺依赖性抗体反应的差异耐受性。
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