自身载体在免疫应答和免疫耐受中的作用。I. 半抗原化同基因淋巴细胞诱导的B细胞无反应性和细胞毒性T细胞免疫
Role of self-carriers in the immune response and tolerance. I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells.
作者信息
Scott D W, Long C A
出版信息
J Exp Med. 1976 Nov 2;144(5):1369-74. doi: 10.1084/jem.144.5.1369.
Abstract
Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells,but go on to generate cytotoxic T cells directed at hapten-modified H-2.These results suggest that hapten-modifeid spleen cells may differentially induce B-cell tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.
摘要
用经三硝基苯（TNP）修饰的同基因脾细胞培养正常脾细胞时，这些正常脾细胞无法对TNP - 聚蔗糖或TNP - 红细胞产生抗TNP抗体形成细胞（PFC）反应，但会继续产生针对经半抗原修饰的H - 2的细胞毒性T细胞。这些结果表明，经半抗原修饰的脾细胞可能会差异性地诱导B细胞耐受和T（Ly 2,3）细胞免疫。文中讨论了淋巴细胞亚群对修饰自身的差异性反应。
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Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten.非抗原性与免疫耐受性：载体在诱导对半抗原的耐受性中的作用。
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Radioresistance of the enhancing effect of cells from carrier-immunized mice in an in vitro primary immune response.载体免疫小鼠细胞在体外初次免疫应答中增强作用的放射抗性。
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