[The effect of glucose on the biosynthesis of extracellular enzymes by Streptomyces recifensis var. lyticus 2435 and its mutants].

Different glucose concentrations have been studied for their effect on biosynthesis of bacterio- and proteolytic enzymes in Streptomyces recifensis var. lyticus 2435 and strains II-29 and 2P-15 obtained from the latter. It has been established that synthesis of enzymes by the parent strain 2435 was subjected to catabolite repression: synthesis of proteolytic and staphylolytic enzymes was the most sensitive to glucose, synthesis of glucosidases was less sensitive. The role of catabolite repression in regulation of synthesis of bacteriolytic enzymes to the latter in strain II-29 and rifamycin-resistant mutant 2P-15 is essentially decreased. As compared with the initial strains, the high level of activity of lytic enzymes in the strain 2P-15 is achieved at higher glucose concentrations in the fermentation medium, synthesis of staphylolysins and glucosideases are inhibited inconsiderably at 2% and 4% content of glucose, in medium respectively and it does not decrease under further increase of glucose concentration.