Hulme M, Sahgal A, Iversen S D
Psychopharmacology (Berl). 1979 Mar 29;62(1):71-8. doi: 10.1007/BF00426038.
An experiment was carried out in the pigeon to assess the effects of sodium amylobarbitone (SAB) on memory, using a delayed pair comparison task. Performance was disrupted at all delays by doses of 10 and 20 mg/kg SAB and it was concluded that this effect was not due to perceptual impairment or stereotyped responding, which the drug might have caused, since performance on a visual discrimination task was unaffected by the same doses of SAB. Two further experiments assessed proactive and retroactive effects by varying the inter-trial interval and by introducing an irrelevant orange stimulus at various stages of the delay interval. Although these manipulations disrupted performance, there was no evidence to suggest that the drug potentiated their effects in a specific manner. The results are discussed in terms of an encoding hypothesis, and some reference is made to the possible neuropharmacological basis of action of this drug.
在鸽子身上进行了一项实验，以使用延迟配对比较任务评估戊巴比妥钠（SAB）对记忆的影响。10毫克/千克和20毫克/千克剂量的SAB在所有延迟情况下均会干扰表现，并且得出结论，这种影响并非由该药物可能导致的感知障碍或刻板反应引起，因为相同剂量的SAB对视觉辨别任务的表现没有影响。另外两项实验通过改变试验间隔以及在延迟间隔的不同阶段引入无关的橙色刺激来评估前摄和 retroactive 效应。尽管这些操作干扰了表现，但没有证据表明该药物以特定方式增强了它们的效应。根据编码假说对结果进行了讨论，并提及了该药物可能的神经药理学作用基础。 （注：原文中“retroactive”翻译为“追溯的”，但结合语境这里可能是想表达“倒摄的”，不过按照要求未做修改。）
