Sahgal A, Iversen S D
Psychopharmacology (Berl). 1978 Sep 15;59(1):57-64. doi: 10.1007/BF00428031.
Five pigeons were successfully taught a variation of the Konorski delayed pair comparison task, using a red and a green stimulus. The bird was required to respond to the left or right hand key, depending on whether the 2 successively presented centre key stimuli were the same (left) or different (right). The delay intervals ranged from zero to 9 s, and stable performance decrements (with increasing delay) were obtained. Chlordiazepoxide which, it has been argued, produces behavioural changes similar to those observed after hippocampal lesions was found to disrupt performance at doses greater than 4 mg/kg (i.m.). All delays (including zero) were affected. Some interpretations of this result in terms of encoding and attention are discussed, and some reference made to the possible neuropharmacological basis of this drug action.
五只鸽子成功学会了Konorski延迟配对比较任务的一种变体，使用红色和绿色刺激物。要求鸽子根据先后呈现的两个中央按键刺激物是相同（按左手键）还是不同（按右手键），对左手或右手按键做出反应。延迟间隔从零到9秒，并且获得了稳定的（随着延迟增加的）性能下降。有人认为氯氮卓产生的行为变化与海马损伤后观察到的变化相似，结果发现，剂量大于4毫克/千克（肌肉注射）时，氯氮卓会干扰任务表现。所有延迟（包括零延迟）都会受到影响。讨论了关于编码和注意力方面对这一结果的一些解释，并提及了这种药物作用可能的神经药理学基础。
