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Cloning: pathways to a pluripotent future.

作者信息

McLaren A

机构信息

Wellcome/CRC Institute, Cambridge, UK.

出版信息

Science. 2000 Jun 9;288(5472):1775-80. doi: 10.1126/science.288.5472.1775.

DOI:10.1126/science.288.5472.1775
PMID:10877698
Abstract

In this month's essay, Anne McLaren traces the winding and pitted pathways that connect the early days of the cell theory of biology in the 1830s to the new and unfolding era of cloning science and technology that came to worldwide attention in 1997 with the announcement of the birth of Dolly, the Scottish cloned sheep. The possibilities, including the potential for new medical treatments and perhaps even human cloning, are fantastic ... and ethically charged.

摘要

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Sheep and Goat Genome Engineering: From Random Transgenesis to the CRISPR Era.绵羊和山羊基因组工程：从随机转基因到CRISPR时代
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Cloning humans? Biological, ethical, and social considerations.克隆人类？生物学、伦理及社会考量
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8879-86. doi: 10.1073/pnas.1501798112. Epub 2015 Jul 20.
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Nuclear reprogramming in mammalian somatic cell nuclear cloning.哺乳动物体细胞核移植中的核重编程
Cytogenet Genome Res. 2004;105(2-4):285-91. doi: 10.1159/000078200.
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Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn-imprinting region in mouse embryonic stem cells.体外操作对小鼠胚胎干细胞中Snurf/Snrpn印记区域甲基化模式稳定性的影响。
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The first half-century of nuclear transplantation.核移植的头半个世纪。
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