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[抗大鼠和人类大脑皮质及白质抗体对异种T细胞和B细胞的影响]

[Effect of antibodies to rat and human cerebral cortex and white matter on heterologous T- and B-cells].

作者信息

Belokrylov G A, Zhitnukhin Iu L

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1976 Sep(9):66-70.

PMID:1087798
Abstract

A study was made of the cytotoxic and complement-fixation activity of the antisera to the cortex and white matter of the rat and human brain upon the mouse and rat thymus and bone marrow cells. The cytotoxicity test proved to be more sensitive and precise. Cytotoxins to rodent thymocytes were revealed on ly in the antisera against the human brain cortex; at the same time they were revealed both in the antisera against the cortex and against the white matter of the rat brain (much more was found in the former). The sera against the rat brain cortex lost their cytotoxicity after the exhaustion with the same antigen, but retained it when the exhaustion was carried out by the white matter.

摘要

对大鼠和人脑皮质及白质抗血清对小鼠和大鼠胸腺及骨髓细胞的细胞毒性和补体固定活性进行了研究。细胞毒性试验被证明更敏感和精确。仅在针对人脑皮质的抗血清中发现了对啮齿动物胸腺细胞的细胞毒素;同时,在针对大鼠脑皮质和白质的抗血清中均发现了这种细胞毒素(前者中发现的更多)。用相同抗原耗尽后,针对大鼠脑皮质的血清失去了细胞毒性,但用白质进行耗尽时,其细胞毒性得以保留。

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