抗坏血酸氧化是其转运至大鼠肝微粒体囊泡的一个前提条件。
Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles.
作者信息
Csala M, Mile V, Benedetti A, Mandl J, Bánhegyi G
机构信息
Department of Medical Chemistry, Semmelweis University, P.O.B. 260, H-1444 Budapest, Hungary.
出版信息
Biochem J. 2000 Jul 15;349(Pt 2):413-5. doi: 10.1042/0264-6021:3490413.
Abstract
Oxidation and uptake of ascorbate show similar time courses in rat liver microsomal vesicles: a rapid burst phase is followed by a slower process. Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin) also effectively decreased the uptake of ascorbate. The results show that dehydroascorbate is the transport form of ascorbate at the membrane of the endoplasmic reticulum.
摘要
抗坏血酸的氧化和摄取在大鼠肝脏微粒体囊泡中呈现相似的时间进程
快速爆发阶段之后是一个较慢的过程。抗坏血酸氧化抑制剂（丙胺太林、益康唑或槲皮素）也有效地降低了抗坏血酸的摄取。结果表明，脱氢抗坏血酸是内质网膜上抗坏血酸的转运形式。
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