Deb B C, Sen Gupta P G, De S P, Sil J, Sikdar S N, Pal S C
Bull World Health Organ. 1976;54(2):171-5.
Sulfadoxine, a long-acting sulfonamide, and tetracycline were compared as regards their effectiveness in reducing transmission of cholera infection among the contacts of cholera patients in Calcutta. A total of 109 healthy family contacts of confirmed hospitalized cholera patients were treated with a single oral dose of sulfadoxine graded according to age. Another similar group of 101 contacts received 6 divided doses of oral tetracycline over a period of 3 days. All these contacts were bacteriologically examined for 15 days. Results showed that tetracycline was effective in significantly reducing the load of cholera infection from the 2nd to 6th day, while sulfadoxine was effective from the 3rd to the 6th day. The advantages and disadvantages of the two drugs as chemoprophylactic agents in cholera are discussed.
长效磺胺类药物磺胺多辛与四环素在减少加尔各答霍乱患者接触者中霍乱感染传播方面的有效性进行了比较。总共109名确诊住院霍乱患者的健康家庭接触者接受了根据年龄分级的单剂量口服磺胺多辛治疗。另一组101名类似的接触者在3天内分6次口服四环素。所有这些接触者均接受了15天的细菌学检查。结果表明，四环素在第2天至第6天能有效显著降低霍乱感染负荷，而磺胺多辛在第3天至第6天有效。讨论了这两种药物作为霍乱化学预防剂的优缺点。
