McCormack W M, Chowdhury A M, Jahangir N, Ahmed A B, Mosley W H
Bull World Health Organ. 1968;38(5):787-92.
The evaluation of tetracycline as a chemoprophylactic agent for cholera is described. Families of cholera patients were divided into 4 groups by strict rotation. The first group received multivitamin preparations and served as the control. The second received 1.0 g of tetracycline, divided into 4 doses, daily for 5 days, the third received 1.0 g of tetracycline in a single dose daily for 5 days, and the fourth received a single dose of 1.0 g of tetracycline. All families were visited daily for 10 days, a rectal swab being taken from each family member on each occasion. Tetracycline given daily for 5 days, either in divided doses or in a single daily dose, was effective in preventing subsequent infection. A single dose of tetracycline was less effective. The indications for chemoprophylaxis in cholera are discussed.
本文描述了对四环素作为霍乱化学预防剂的评估。霍乱患者家属通过严格轮换分为4组。第一组接受多种维生素制剂，作为对照组。第二组每天服用1.0克四环素，分4次服用，共5天；第三组每天单次服用1.0克四环素，共5天；第四组单次服用1.0克四环素。对所有家庭进行为期10天的每日访视，每次对每个家庭成员采集直肠拭子。连续5天每日服用四环素，无论是分次服用还是每日单次服用，均能有效预防后续感染。单次服用四环素效果较差。文中还讨论了霍乱化学预防的指征。
