Gupta P G, Sircar B K, Mondal S, De S P, Sen D, Sikder S N, Deb B C, Pal S C
Bull World Health Organ. 1978;56(2):323-6.
Doxycycline was used among the family contacts of hospitalized cholera patients in Calcutta to determine its effectiveness in controlling transmission of V. cholerae infection. A total of 137 such contacts were given a single oral dose of doxycycline in graded doses according to age. A similar group of 139 contacts received a single dose of multivitamins as placebo. All 276 contacts were examined bacteriologically daily for 10 days for the presence of V. cholerae in their stools. The results showed that doxycycline was effective in significantly reducing the load of V. cholerae infection for up to 5 days following treatment.
在加尔各答，对住院霍乱患者的家庭接触者使用强力霉素，以确定其在控制霍乱弧菌感染传播方面的有效性。根据年龄，总共137名此类接触者被给予单剂量的分级强力霉素口服。另一组139名接触者接受单剂量多种维生素作为安慰剂。所有276名接触者每天接受10天的粪便细菌学检查，以检测粪便中是否存在霍乱弧菌。结果表明，强力霉素在治疗后长达5天内可有效显著降低霍乱弧菌感染负荷。
