New antineoplastic prenylhydroquinones. Synthesis and evaluation.
作者信息
Molinari A, Oliva A, Aguilera N, Miguel del Corral J M, Castro M A, Gordaliza M, García-Grávalos M D, San Feliciano A
机构信息
Instituto de Química, Universidad Católica de Valparaíso, Chile.
出版信息
Bioorg Med Chem. 2000 May;8(5):1027-32. doi: 10.1016/s0968-0896(00)00032-8.
Abstract
Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.
摘要
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