Straube A, Ditterich J, Oertel W, Kupsch A
Neurologische Poliklinik, Klinikum Grosshadern, Munich, Germany.
J Neurol. 1998 Feb;245(2):101-5. doi: 10.1007/s004150050186.
Chronic electrical stimulation of the posteroventral internal pallidum, a recently developed treatment option in advanced Parkinson's disease (PD), improves bradykinesia, rigidity and medication-induced dyskinesia. Apart from disturbances of the somatic motor system, PD is also characterized by disturbances of saccadic eye movements with hypometric and delayed internally guided saccades. We examined these internally guided eye movements (memory-guided and anti-task saccades) in a patient with bilaterally implanted stimulation electrodes, when stimulation was turned on and off. The electrical stimulation not only improved the bradykinesia and rigidity, but also the internally guided saccades by shortening the latency of the anti-saccades and increasing the gain of the memory-guided saccades. This finding supports the idea that the oculomotor pathways through the basal ganglia are organized like the somatic motor pathways and that stimulation of the posteroventral pallidum influences both.
慢性电刺激苍白球腹后内侧部是晚期帕金森病（PD）最近开发的一种治疗选择，可改善运动迟缓、僵硬和药物引起的运动障碍。除了躯体运动系统紊乱外，PD的特征还包括扫视性眼球运动紊乱，伴有测角不足和延迟的内源性引导扫视。我们在一名双侧植入刺激电极的患者中，研究了刺激开启和关闭时的这些内源性引导眼球运动（记忆引导扫视和反任务扫视）。电刺激不仅改善了运动迟缓和僵硬，还通过缩短反扫视的潜伏期和增加记忆引导扫视的增益改善了内源性引导扫视。这一发现支持了这样一种观点，即通过基底神经节的动眼神经通路与躯体运动通路的组织方式相似，并且对苍白球腹后部的刺激会对两者产生影响。
