Owu D U, Orie N N, Osim E E
Department of Physiology, College of Medical Sciences, University of Calabar, Nigeria.
Afr J Med Med Sci. 1997 Mar-Jun;26(1-2):83-6.
The responsiveness of the rat aorta after chronic consumption of 15% (wt/wt) fresh and thermally oxidized palm oil diets was studied under standard organ bath procedures. Aortic rings from the oxidized oil-fed group showed significantly (P < 0.05) enhanced vascular responses to noradrenaline and potassium chloride when compared with the control and fresh palm oil-fed groups. The maximum tensions were 285.10 +/- 30 mg/mg tissue weight for the oxidized oil-fed group and 148.98 +/- 36 mg/mg for the control in response to noradrenaline. The fresh oil-fed group produced maximum tension of 133.9 +/- 20 mg/mg which was not significantly different from the control. The trend was similar with potassium chloride. The maximum tensions were 206.31 +/- 25 mg/mg for the oxidized oil-fed group and 93.33 +/- 13 mg/mg for the control group. The fresh oil-fed group produced maximum tension of 109.31 +/- 7.8 mg/mg which was not significantly different from the control. Relaxation to acetylcholine was significantly (P < 0.01) attenuated in the aortic rings obtained from the oxidized palm oil-fed group when compared with the control and fresh palm oil-fed groups. The percentage maximum relaxations to acetylcholine were 28.1 +/- 6.7% in the oxidized oil-fed group, 71.4 +/- 6.0% in control and 78.2 +/- 6.0% in the fresh oil-fed groups. The relaxation in the fresh oil-fed group was not significantly different from control. These results suggest that functional changes occur in rat blood vessels after chronic consumption of thermally oxidized palm oil.
在标准器官浴程序下，研究了大鼠长期食用15%（重量/重量）新鲜和热氧化棕榈油饮食后主动脉的反应性。与对照组和新鲜棕榈油喂养组相比，氧化油喂养组的主动脉环对去甲肾上腺素和氯化钾的血管反应显著增强（P<0.05）。氧化油喂养组对去甲肾上腺素的最大张力为285.10±30mg/mg组织重量，对照组为148.98±36mg/mg。新鲜油喂养组产生的最大张力为133.9±20mg/mg，与对照组无显著差异。氯化钾的情况趋势相似。氧化油喂养组的最大张力为206.31±25mg/mg，对照组为93.33±13mg/mg。新鲜油喂养组产生的最大张力为109.31±7.8mg/mg，与对照组无显著差异。与对照组和新鲜棕榈油喂养组相比，氧化棕榈油喂养组的主动脉环对乙酰胆碱的舒张作用显著减弱（P<0.01）。氧化油喂养组对乙酰胆碱的最大舒张百分比为28.1±6.7%，对照组为71.4±6.0%，新鲜油喂养组为78.2±6.0%。新鲜油喂养组的舒张与对照组无显著差异。这些结果表明，大鼠长期食用热氧化棕榈油后血管功能会发生变化。
