Osim E E, Owu D U, Etta K M
Department of Physiology, College of Medical Sciences, University of Calabar, Nigeria.
Afr J Med Med Sci. 1996 Dec;25(4):335-40.
The mean arterial blood pressure (MAP) and plasma lipid profile of rats following chronic consumption of a diet containing 15% palm oil (fresh or oxidized) were studied. Rats were allowed to feed on either a fresh or oxidized palm oil diet for 18 weeks and their effects were compared with a control group receiving normal rat feed. Mean arterial blood pressures were 128.0 +/- 2.3 mmHg (mean +/- SEM) for the control, 135.0 +/- 2.4 mmHg for the fresh-oil fed group and 147 +/- 2.5 mmHg for the oxidized oil-fed group. The oxidized oil-fed group had a significantly greater rise in mean arterial blood pressure than the control and fresh oil-fed groups (P < 0.01 and 0.05, respectively). Mean arterial blood pressure was not significantly elevated in the fresh oil-fed group than the control. Low density lipoprotein cholesterol (LDL) levels were 1.51 +/- 0.07 mMol/L for the control, 1.62 +/- 0.03 mMol/L for the fresh oil-fed group and 1.78 +/- 0.03 mMol/L for the oxidized oil-fed group. The values were not significantly different in the control and the fresh oil groups. LDL level was significantly higher in the oxidized than in the control (P < 0.01) and fresh oil-fed groups (P < 0.05). Total cholesterol for the two test groups were significantly (P < 0.05) higher than the control, while the value in the oxidized oil group was also significantly (P < 0.05) higher than the fresh oil-fed group. There was no significant difference in high density lipoprotein cholesterol (HDLP) levels in the three groups. The significantly elevated MAP in the oxidized oil-fed rats when compared to the fresh oil-fed and control rats may be due to thermoxidation of the fresh oil that produced significantly higher levels of LDL and total cholesterol which predisposes to high blood pressure.
研究了长期食用含15%棕榈油（新鲜或氧化的）饮食的大鼠的平均动脉血压（MAP）和血浆脂质谱。大鼠被允许食用新鲜或氧化棕榈油饮食18周，并将其影响与接受正常大鼠饲料的对照组进行比较。对照组的平均动脉血压为128.0±2.3 mmHg（平均值±标准误），新鲜油喂养组为135.0±2.4 mmHg，氧化油喂养组为147±2.5 mmHg。氧化油喂养组的平均动脉血压升高幅度显著大于对照组和新鲜油喂养组（分别为P<0.01和0.05）。新鲜油喂养组的平均动脉血压与对照组相比无显著升高。对照组的低密度脂蛋白胆固醇（LDL）水平为1.51±0.07 mMol/L，新鲜油喂养组为1.62±0.03 mMol/L，氧化油喂养组为1.78±0.03 mMol/L。对照组和新鲜油组的值无显著差异。氧化组的LDL水平显著高于对照组（P<0.01）和新鲜油喂养组（P<0.05）。两个试验组的总胆固醇均显著高于对照组（P<0.05），而氧化油组的值也显著高于新鲜油喂养组（P<0.05）。三组的高密度脂蛋白胆固醇（HDLP）水平无显著差异。与新鲜油喂养和对照大鼠相比，氧化油喂养大鼠的MAP显著升高，可能是由于新鲜油的热氧化产生了显著更高水平的LDL和总胆固醇，从而易患高血压。
