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人多形核白细胞和单核细胞对唾液支原体的吞噬作用。

Phagocytosis of Mycoplasma salivarium by human polymorphonuclear leukocytes and monocytes.

作者信息

Parkinson C F, Carter P B

出版信息

Infect Immun. 1975 Feb;11(2):405-14. doi: 10.1128/iai.11.2.405-414.1975.

DOI:10.1128/iai.11.2.405-414.1975
PMID:1089604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415077/
Abstract

Mycoplasmacial activity was exhibited by human peripheal blood leukocytes in the absence of detectable specific antiserum. After incubation of varying concentrations of Mycoplasma salivarium with leukocytes, changes in colony-forming units (CFU) of this species per millilter occurred. The most noticeable decrease in CFU per milliliter was then the incubation mixtures contained five mycoplasmas per leukocyte. At this ratio, the mycoplasmacial min of incubation. Continued incubation demonstrated a tenfold decrease in CFU per milliliter by 4 h. Electron micrographs of incubated mixtures of human leukocytes and M. salivarium showed this mycoplasma to be phagocytized by monocytes and neutrophils whenever mutual contact or pseudopodial formation occurred. The process was continuous. Numerous phagocytic vacuoles developed which contained multiple ingested microorganisms. After the cytoplasmic granules of the leukocytes fused with the phagocytic vacuole, the phagocytized mycoplasmas became disrupted and unrecognizable.

摘要

在没有可检测到的特异性抗血清的情况下，人外周血白细胞表现出支原体活性。将不同浓度的唾液支原体与白细胞孵育后，每毫升该菌种的集落形成单位（CFU）发生了变化。每毫升CFU最显著的降低是在孵育混合物中每个白细胞含有五个支原体时。在此比例下，支原体在孵育过程中逐渐减少。持续孵育显示，到4小时时每毫升CFU下降了十倍。人白细胞与唾液支原体孵育混合物的电子显微镜照片显示，只要发生相互接触或伪足形成，这种支原体就会被单核细胞和中性粒细胞吞噬。这个过程是持续的。形成了许多含有多个摄入微生物的吞噬泡。白细胞的细胞质颗粒与吞噬泡融合后，被吞噬的支原体被破坏且无法辨认。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/aa83cd80ecbf/iai00230-0199-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/aa83cd80ecbf/iai00230-0199-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/1b3fe707525b/iai00230-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/f748f6254ee4/iai00230-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/221a2441ed4f/iai00230-0194-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/343d67cbd4f6/iai00230-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/0c9b1d237993/iai00230-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/c855727f563b/iai00230-0195-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/145fd388a002/iai00230-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/d11d4129ff7e/iai00230-0196-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/ed26ef204ed4/iai00230-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/53ed6dda5577/iai00230-0198-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/7332811915c9/iai00230-0199-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8913/415077/aa83cd80ecbf/iai00230-0199-b.jpg

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引用本文的文献

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本文引用的文献

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MYCOPLASMA SPECIES IDENTIFICATION BASED UPON GROWTH INHIBITION BY SPECIFIC ANTISERA.基于特异性抗血清生长抑制的支原体种类鉴定
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THE OCCURRENCE OF MYCOPLASMA (PLEUROPNEUMONIA-LIKE ORGANISMS, PPLO) IN THE ORAL CAVITY OF DENTULOUS AND EDENTULOUS SUBJECTS.无牙颌与缺牙患者口腔中支原体（类胸膜肺炎微生物，PPLO）的发生情况。
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Antigenic properties of pleuropneumonia-like organisms from tissue cell cultures and the human genital area.来自组织细胞培养物及人类生殖器部位的类胸膜肺炎微生物的抗原特性。
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The interaction of mycoplasmas with mammalian cells. II. Monocytes and lymphocytes.支原体与哺乳动物细胞的相互作用。II. 单核细胞和淋巴细胞。
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The interaction of mycoplasmas with mammalian cells. I. HeLa cells, neutrophils, and eosinophils.支原体与哺乳动物细胞的相互作用。I. 宫颈癌细胞、中性粒细胞和嗜酸性粒细胞。
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Mycoplasmacidal effect of polymorphonuclear leukocyte extract.
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Periodontal disease: a model for the study of inflammation.
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Neutral proteases confined to one class of lysosomes of human polymorphonuclear leukocytes.中性蛋白酶局限于人类多形核白细胞的一类溶酶体中。
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The interaction in vitro of Mycoplasma pulmonis with mouse peritoneal macrophages and L-cells.肺炎支原体与小鼠腹腔巨噬细胞和L细胞的体外相互作用。
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