mut - 25，一种与大肠杆菌中purA相关的致突变基因的突变。
mut-25, a mutation to mutator linked to purA in Escherichia coli.
作者信息
Siegel E C, Ivers J J
出版信息
J Bacteriol. 1975 Feb;121(2):524-30. doi: 10.1128/jb.121.2.524-530.1975.
Abstract
The mutation mut-25 that results in a mutator phenotype is closely linked to purA on the chromosome of Escherichia coli. The gene order in this region is ampA mut-25 purA. purA mut-25 double mutants retained mutator activity indicating that mut-25 is not a mutation in the purA gene. The repair mutations uvrA6, recA56, and exrA1 had no effect on mutation frequencies in mut-25 strains, and mut-25 strains were normally resistant to ultraviolet irradiation. Frequencies of host range mutations were not increased in phages T1, T2, and T7 grown on mut-25 strains. mut-25 could act trans, reverting the trpA46 mutation either on the chromosome or on an F episome. The transitions AT yields GC (adenine-thymine yields guanine-cytosine) and GC yields AT were induced by mut-25.
摘要
导致突变体表型的突变体mut-25与大肠杆菌染色体上的purA紧密连锁。该区域的基因顺序为ampA mut-25 purA。purA mut-25双突变体保留了突变活性，表明mut-25不是purA基因中的突变。修复突变uvrA6、recA56和exrA1对mut-25菌株的突变频率没有影响，并且mut-25菌株通常对紫外线照射具有抗性。在mut-25菌株上生长的噬菌体T1、T2和T7中，宿主范围突变的频率没有增加。mut-25可以反式作用，使染色体上或F附加体上的trpA46突变回复突变。mut-25诱导了AT向GC（腺嘌呤-胸腺嘧啶转变为鸟嘌呤-胞嘧啶）和GC向AT的转变。
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J Bacteriol. 1975 Feb;121(2):524-30. doi: 10.1128/jb.121.2.524-530.1975.
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