Patton W C, Berger M J, Thompson I E, Chong A P, Grimes E M, Taymor M L
Am J Obstet Gynecol. 1975 Feb 1;121(3):382-6. doi: 10.1016/0002-9378(75)90017-4.
Synthetic luteinizing hormone-releasing hormone (LH-RH) was administered intravenously to 17 women with polycystic ovary disease (PPCO), 16 women with hypothalamic amenorrhea (HA), and nine women with normal cycles. The serum levels of follicle-stimulating hormone (FHS) and luteinizing hormone (LH) were measured at frequent intervals before and after LH-RH injection. The PCO patients were arbitrarily divided into two groups on the basis of ovarian morphology. The eight patients with large, "typical" PCO's (Type I) showed a greater LH response and a lower FSH response to LH-RH than did the nine patients with smaller, "atypical" PCO's (Type II). The LH response in Type I co was also greater than that in HA, but the FSH response in both types of PCO was significantly less than that in HA. The gonadotropin responses to LH-RH in Type I PCO were quite similar to those occurring in normal women during the two to three days prededing ovulation. The results suggest that excessive LH secretion and/or impaired FSH secretion may be etiologically significant in PCO but do not clearly differentiate whether the stimulus for this pattern of gonadortopin secretion occurs at the hypothatamic or pituitary level.
对17名多囊卵巢疾病（PCO）患者、16名下丘脑性闭经（HA）患者和9名月经周期正常的女性静脉注射合成促黄体生成激素释放激素（LH-RH）。在注射LH-RH前后频繁测量血清促卵泡生成激素（FHS）和促黄体生成激素（LH）水平。根据卵巢形态，将PCO患者随机分为两组。8名有大的“典型”PCO的患者（I型）与9名有较小的“非典型”PCO的患者（II型）相比，对LH-RH表现出更大的LH反应和更低的FSH反应。I型PCO患者的LH反应也大于HA患者，但两种类型PCO患者的FSH反应均显著低于HA患者。I型PCO患者对LH-RH的促性腺激素反应与正常女性排卵前两到三天的反应非常相似。结果表明，LH分泌过多和/或FSH分泌受损在PCO的病因学上可能具有重要意义，但不能明确区分这种促性腺激素分泌模式的刺激是发生在下丘脑还是垂体水平。
