早产婴儿呼吸道合胞病毒感染住院治疗——呼吸道合胞病毒免疫球蛋白使用的意义
Hospitalisation for RSV infection in ex-preterm infants-implications for use of RSV immune globulin.
作者信息
Thomas M, Bedford-Russell A, Sharland M
机构信息
Neonatal Unit, St George's Hospital, Blackshaw Road, London SW17 0QT, UK.
出版信息
Arch Dis Child. 2000 Aug;83(2):122-7. doi: 10.1136/adc.83.2.122.
BACKGROUND
Respiratory syncytial virus (RSV) specific immune globulin is now being marketed for prevention of RSV infection in ex-preterm infants. However, there are no published UK data on the morbidity or mortality from RSV in these infants.
AIMS
To determine the morbidity and mortality from RSV infection in a cohort of infants previously treated at a regional neonatal unit, and compare the cost of hospitalisation for RSV with the potential cost of administering RSV immune globulin (RSV-IG) prophylaxis.
METHODS
Infants born at a gestation of less than 32 weeks were studied. Details of admissions for respiratory illness in the first two years of life were collected from hospital records, referring hospitals, and general practitioners.
RESULTS
Data on 82 infants were collected. Up to three RSV seasons were encountered. The hospitalisation rate for confirmed RSV infection for the first season encountered was 4%. Rates of ward and paediatric intensive care unit admission were higher for infants with chronic lung disease. There were no deaths from RSV. RSV-IG would not have been cost effective for most infants.
CONCLUSION
The morbidity and mortality rates from RSV observed in this group do not support the widespread introduction of RSV-IG prophylaxis for ex-preterm infants.
背景
呼吸道合胞病毒（RSV）特异性免疫球蛋白目前已上市，用于预防早产婴儿感染RSV。然而，英国尚无关于这些婴儿RSV发病率或死亡率的公开数据。
目的
确定一组曾在地区新生儿病房接受治疗的婴儿中RSV感染的发病率和死亡率，并比较RSV住院费用与使用RSV免疫球蛋白（RSV-IG）预防的潜在费用。
方法
对孕周小于32周出生的婴儿进行研究。从医院记录、转诊医院和全科医生处收集婴儿出生后前两年呼吸系统疾病的住院详情。
结果
收集了82名婴儿的数据。经历了多达三个RSV季节。第一个RSV季节确诊感染RSV的住院率为4%。慢性肺病婴儿的病房和儿科重症监护病房住院率更高。没有因RSV死亡的病例。对大多数婴儿而言，RSV-IG不具有成本效益。
结论
该组中观察到的RSV发病率和死亡率不支持对早产婴儿广泛采用RSV-IG预防措施。
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